San Domenico is a Gothic-style Roman Catholic co-cathedral located on Largo Maranesi in Fermo, in the region of Marche, Italy.
The Dominicans had come to Fermo after San Domenico di Guzman visited the town in 1214.
The present brick façade has a rose window and a single portal built in late-Romanesque-Gothic-style in 1455.
The inner arch of the portal is rounded with a floral motif, while the outer border peaks in an acute angle.
The chapel of the Holy Sacrament once held the painting of the Last Supper by Nicola Antonio Monti.