A church was known at the site since 1240,[1] and construction of the present structure began in 1303.

In 1575, Cardinal Ferdinando de' Medici conceded the monastery to the Capuchins.

Gravely damaged during World War II, it was subsequently restored.

The interior contains frescoes of the Madonna and child and a wooden crucifix, both from the 14th century.

Here, before the Allied aerial bombings, was the tomb of the Pisan architect Alessandro Gherardesca.