The San Esteban Apedreado was a fifth-rate frigate in the Spanish navy that ran ashore and was damaged in the Rio de la Plata in 1741 and was broken up in 1744 or 1745.

The San Esteban Apedreado was a fifth-rate frigate built in the Guarnizo shipyard near Santander, Spain, by Lorenzo Arzueta.

In April of that year, it was in the Rio de la Plata with Hermione, San Francisco Javier, and Paloma Indiana.

[1] The San Estéban Apedreado left Ferrol on 7 October 1740 in Vice-Admiral José Alfonso Pizarro's squadron, but was forced back due to bad weather.

[2] The Spanish government ordered General José Pizarro to respond with his squadron consisting of the ships Asia (64), Guipúzcoa (74), Hermione (54) and Esperanza (50) and the frigate San Estéban (40).