San Francesco della Vigna is a Roman Catholic church in the Sestiere of Castello in Venice, northern Italy.

A tiny chapel already on the site recalled the spot where an angel supposedly had pronounced Pax tibi Marce, evangelista meus to the shipwrecked Saint Mark, patron of Venice.

The church was designed in sober Renaissance style by Jacopo Sansovino in 1554, with the advice of the Franciscan friar, Fra Francesco Zorzi.

It is thought that the patrician Daniele Barbaro lobbied for the commission to be switched from Sansovino to Palladio in 1562, convincing the then Patriarch, Giovanni Grimani.

The façade contains two large bronze statues of Moses and Saint Paul (1592), actively stepping forward from their shallow niches, sculpted by Tiziano Aspetti.

Below, a frieze dedication of the church states: Deo utriusque templi aedificatori ac reparatori (God, builder and restorer of both temples) is engraved.

Four marble plaques state: Ac cede ad hoc / ne deseras spirituale / non sine iugi exteriori / interiorique bello (Enter here / not abandoning the spirit / not without detaching yourself from the exterior world / and making your interior beautiful).

The Grimani chapel (first in the left aisle) is decorated with ceiling paintings by Battista Franco, and murals and altarpiece by Federico Zuccari.

It was erected at the expense of Matteo Goretto with an underlying altar dedicated to St. Matthew with a painting depicting the apostle of Francesco Montemezzano.

On both sides in niches of the allegory of the Peace in bronze by Tiziano Aspetti who is the author of the statues of the Palladian facade of the church.

The vow will not be respected and it is only 150 years later that the chapel is erected on the occasion of the reconstruction of San Francesco della Vigna.

On the left side: The adoration of the mages, a copy of the painting by Federico Zuccari in the Grimani chapel, which is very degraded (oil on marble).

On the right side of the vestibule is a picture by Palma il giovane: the flagellation; below, an icon (tempera on wood), anonymous work of the end of the XIVth century: Madonna dell'Umiltà .

The vault is decorated with stucco of the eighteenth century, with a central medallion Saint Peter of Alcantara in Glory (1765) by Francesco Fontebasso.

A lunette was added to the painting later, depicting God the Father and the Holy Ghost (early 16th century) by Benedetto Rusconi (il Diana).