It is dedicated to St Francis of Paola, the founder of the Order of Minims, whose friars serve this church and whose Generalate is attached to it, and is located in the Monti rione.

The monastery was refurbished under Father Francesco Zavaroni di Montalto, General of the order, and using as an architect Luigi Berettoni.

[1] The late Baroque high altar was made by Giovanni Antonio de Rossi c. 1655 (who is also credited with the church's wooden tabernacle, set into a sculptured entrance of a military pavilion).

The church contains an icon of Francis said to be a copy of a portrait, along with scenes from the life and miracles of the saint which can be seen in the sacristy and examples by Giuseppe Bartolomeo Chiari in the second chapel on the south side.

The ceiling of the sacristy was painted by Sassoferrato, with a motif of "The Blessed Virgin appearing to St Francis of Paola".