[1] The reserve is used to promote San Francisco Bay wetlands and estuary research, education, and stewardship.
[2] The reserve’s headquarters is located at San Francisco State University's Romberg Tiburon Campus.
[2] In the 1990s, Dr. Roger Crawford from SFSU received a grant from NOAA to explore the potential for establishing a NERR in San Francisco Bay.
Dr. Vasey and a team of scientists recommended that the reserve be designed to include some of the last remaining high-quality tidal wetlands in the San Francisco Estuary.
[2] The San Francisco Bay NERR consists of two sites in the San Francisco Bay Area which total 3,710 acres:[2] The reserve's lead federal agency is the National Oceanic and Atmospheric Administration (NOAA) and the lead state agency is San Francisco State University.