San Francisco Church was a Roman Catholic church along San Francisco and Solana Streets in the walled city of Intramuros, Manila, Philippines.

The church, which used to be the center of the Franciscan missions in the Philippines, was destroyed during the Second World War.

When the Franciscans arrived in the Philippines in 1578, they built a church made of nipa, bamboo and wood, which was inaugurated on August 2 and was dedicated to the Our Lady of Angels.

[2] The statue of Saint Anthony of Padua in the courtyard of Santuario de San Antonio in Forbes Park, Makati, was the lone survivor of the ravages of the war.

[1] After World War II, the site was sold to, and has been occupied by the Mapúa University.