[1] The Royal College of Santa Potenciana was established in 1589 by Philip II - urging the Manila bishop, Domingo de Salazar, OP and the Franciscans.

In 1592, the school drew its charter, cited the main reason for its foundation; the lack of educational opportunity for girls.

By the end of the 18th century, the Palacio del Gobernador was constructed, incorporating the ruins of College of Santa Potenciana.

[2] Government offices were moved into the new building of College of Santa Potenciana in 1866 due to the destruction of Palacio del Gobernador by the 1863 earthquake.

Due to that circumstance, the enrollment rate in the College of Santa Potenciana dropped - with the remaining student boarders transfer to Colegio de Sta.