The health center opened and began serving the sexually active members of San Francisco's communities in 1933.

[1] Its precursor was the Municipal Clinic of San Francisco opened in 1911 to treat prostitutes suffering from the "Red Plague".

[3] City Clinic has done extensive HIV research and how it affects the gay community in San Francisco including tracking the epidemic by zip codes and neighborhoods and mapping the severity of infections.

[2] The clinic offers low cost sexually transmitted disease testing and treatment in addition to birth control to anyone over the age of 12.

[8] Starting in the year 2002 and continuing into 2003, the clinic as part of a national study helped to discover a large increase in gonorrhea and syphilis cases amongst gay and bisexual men that was attributed to the perception that HIV treatments had greatly improved making the condition less life-threatening.

[9] San Francisco City Clinic also does extensive outreach in the predominantly African-American Bayview-Hunters Point district because of the large incidence of new HIV cases in that community.