The Dons are an NCAA Division I college baseball program that competes in the West Coast Conference.

[2] San Francisco has participated in the NCAA Division I baseball tournament three times.

The 2006 team went 38–21 record and won a share of the WCC conference regular season championship.

[3][4][5] Kyle Zimmer became the second Don to be a first round MLB draft selection in 2012, with Tyler Beede became the third in 2014.

USF began receiving reports of sexual misconduct and psychological abuse from the baseball team in late 2021, attributing these allegations eventually to assistant coach Troy Nakamura and firing him in January 2023.