San Francisco Fútbol Club is a professional football team located in La Chorrera, Panamá, that plays in Liga Panameña de Fútbol, the top Panamanian football league.

It has been in the top flight of Panamanian football every year since 1988, when Panama's first professional league was organized.

San Francisco has won 9 Liga Panameña de Fútbol championships, the third highest total of any team since 1988.

The club was founded in September 1971, and began playing in La Chorrera District league.

The club's current name is derived from the patron saint of the La Chorrera District, Francis of Paola (San Francisco de Paula).