San Giorgio a Liri is a comune (municipality) in the Province of Frosinone in the Italian region Lazio, located about 120 kilometres (75 mi) southeast of Rome and about 45 kilometres (28 mi) southeast of Frosinone.

The little town is located in the southernmost part of the province of Frosinone, between the Aurunci mountains and the Liri river.

San Giorgio a Liri borders the following municipalities: Castelnuovo Parano, Esperia, Pignataro Interamna, Sant'Apollinare, Vallemaio.

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