The village of San Gregorio is 12.11 kilometers from the town of L'Aquila, of which it is considered a suburb community (Fraction or Frazione).

The village sits near an active earthquake fault zone in the Valley of the Aterno-Pescara.

San Gregorio is a rural agricultural suburb of the city of L'Aquila and is closely tied to its history.

The area has been inhabited for approximately 1,000 years and initially it did not have a defined city structure.

It was estimated that 95% of San Gregorio's buildings received some type of damage during the earthquake.