San Ignacio del Sara is a town in the Santa Cruz department in the lowlands of the South American Andes state of Bolivia.

San Ignacio del Sara lies in the humid tropical climate before the eastern edge of the Cordillera Oriental Andean mountain chain.

The region has only been developed in the last years and was covered with subtropical rainforest before colonization, but today it is mostly cultivated land.

San Ignacio del Sara lies at a distance of 100 kilometers by road northwest of Santa Cruz, the capital of the department.

Ten kilometers after Portachuelo a country road branches off in a northwesterly direction, which leads through San Ignacio del Sara to Santa Rosa del Sara, where it meets the smooth Route 35, running east-west.