Officially created on April 24, 1931,[2] San Isidro, along with Orrantia and Country Club neighbourhoods, was separated from Miraflores.

San Isidro has become a major financial quarter in recent years, as many banks and businesses left downtown Lima to set up their headquarters in modern office blocks.

For more than fifty years, the border at the western area of the district has been disputed with neighboring Magdalena del Mar.

[3] A judge ordered the councils of both districts to deposit the money of the affected areas' taxpayers in the National Bank of Peru until this long-standing conflict is resolved.

A few museums, as well as the Wak'a Wallamarka, a pre-Inca burying temple which dates back to the 4th century where concerts and exhibitions are held occasionally, showing the cultural heritage of the district.