The church is popular for being the site where water buffalos are made to kneel as tribute to the feast day of the patron saint.

Like the Saint Augustine Parish from the nearby town of Baliuag, the church is also known for featuring one of the longest Holy Week Processions with at least 110 floats.

One of such sources tells that the town was founded in 1749 under the advocation of San Isidro and was subsequently named Pulilan in 1850 by Ignacio Manzanares of Hagonoy in 1871.

The parish of Pulilan was declared as independent some time in 1780 to 1785 according to Martinez de Zuñiga, although it was not indicated in the report to the Augustinian Province in the Philippines in 1760.

[2] On December 13, 2020, Bishop Dennis Villarojo elevated the parish church to the status of a diocesan shrine, making it the seventh in the Diocese of Malolos.