San Lorenzo Isontino (Friulian: San Lurinz; Slovene: Šlovrenc ob Soči) is a comune (municipality) in the Regional decentralization entity of Gorizia in the Italian region of Friuli-Venezia Giulia, located about 40 kilometres (25 mi) northwest of Trieste and about 6 kilometres (4 mi) west of Gorizia.

San Lorenzo Isontino borders the following municipalities: Capriva del Friuli, Farra d'Isonzo, Moraro, Mossa.

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