San Marcello Pistoiese was a comune (municipality) in the Province of Pistoia in the Italian region Tuscany, located about 45 kilometres (28 mi) northwest of Florence and about 15 kilometres (9 mi) northwest of Pistoia.

Before the Roman conquest (3rd-2nd centuries BC), the area was likely inhabited by some Italic tribe, such as the Ligures.

The original settlement started to grow substantially after the construction of the road connecting Pistoia to Modena, which passed through it (1781).

The town has the longest pedestrian suspension bridge in Italy, Ponte sospeso di San Marcello Piteglio, connecting the frazione of Mammiano Basso and Popiglio, and spanning the river Lima.

San Marcello is home to the Pistoia Mountains Astronomical Observatory.