The event consisted of 299 emerging and nine established artists competing over a three month period from December 2021 through February 2022 for the opportunity to represent the nation at the contest.

A promotional tour was initially scheduled, but appearances were subsequently canceled due to the rise in COVID-19 cases occurring at the time.

Performing during the show seventh in the running order, "Stripper" was not announced among the top 10 entries of its semi-final and therefore did not qualify to compete in the final.

[1] The nation's debut entry in the 2008 contest, "Complice" performed by Miodio, failed to qualify for the final and placed last in the semi-final it competed in.

[5] Her song, "Adrenalina", which she performed alongside American rapper Flo Rida, qualified for the final, eventually placing 22nd out of the 26 entries.

Interested artists could apply to partake in the event through the official Una voce per San Marino website,[7] which was open for submissions until 8 January 2022.

Emerging artists attended an academy in the Teatro Titano in the City of San Marino from 13 to 17 December 2021 and 3–11 January 2022, acting as preliminary castings.

[10] The first four members of the jury for this category, announced on 16 November 2021, were Emilio Munda, Roberta Faccani, Roberto Costa [it] and Steve Lyon.

By 16 November 2021, the broadcaster announced it had received over 200 applications, particularly from Germany, Russia and Sweden, but also from other European countries, the United States and Australia.

[12][13] Near the close of the submission period, SMRTV reported that they had received 585 applications overall, out of which 299 were selected to take part in the emerging acts round.

[18] The six Sammarinese acts selected from the auditions were Alibi, Elisa Mazza, Garon × Duan, Giada Pintori, Ginevra Bencivenga and Giulia Vitri.

[33] The winner of the event was Achille Lauro with the song "Stripper", marking the fourth time that an Italian artist had been selected to represent San Marino.

Francesco Viscovo, Gregorio Calculli, Marco Lanciotti, Matteo Ciceroni, Mattia Cutolo and Simon Pietro Manzari.

[37] A promotional music video of the performance during the final Una voce per San Marino had previously been released on the YouTube channel of the Eurovision Song Contest on 23 February.

[41] A previously announced press conference on 22 April, the day before, did take place at the Palazzo Pubblico, where Lauro spoke about the link Eurovision creates between countries.

[42][43] The Eurovision Song Contest 2022 took place at the PalaOlimpico in Turin, Italy, and consisted of two semi-finals held on the respective dates of 10 and 12 May and the final on 14 May 2022.

[46] On 25 January 2022, an allocation draw was held at Palazzo Madama in Turin, which placed each nation into one of the two semi-finals and determined which half of the show they would perform in.

The jury judged each entry based on vocal capacity, the stage performance, the song's composition and originality and the overall impression by the act.

In a statement released during the broadcast of the final, the EBU revealed that six countries, including San Marino, were found to have irregular jury voting patterns during the second semi-final.

The Flemish broadcaster VRT later reported that the juries involved had made agreements to vote for each others' entries to secure qualification to the final.