San Mateo Sindihui is a town and municipality in Oaxaca in south-western Mexico.
The municipality covers an area of 181.17 km².
It is part of the Nochixtlán District in the southeast of the Mixteca Region.
As of 2005, the municipality had a total population of 1,945.
This article about a location in the Mexican state of Oaxaca is a stub.