San Nazzaro Sesia is a comune (municipality) in the Province of Novara in the Italian region Piedmont, located about 70 kilometres (43 mi) northeast of Turin and about 15 kilometres (9 mi) west of Novara.

San Nazzaro Sesia borders the following municipalities: Albano Vercellese, Biandrate, Casalbeltrame, Casalvolone, Greggio, Oldenico, Recetto, and Villata.

It is home to the Abbey of San Nazzaro e Celso, one of the most important Romanesque complexes in Piedmont.

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