San Nicola is a church in Ottana, central Sardinia, Italy.
Dedicated to Saint Nicholas of Myra, it was consecrated in 1160.
It is located on a hill commanding the town and is reached through a staircase.
The interior houses a 16th-century wooden crucifix and a 14th-century polyptych, known as Ottana Altarpiece.
It is attributed to a "Master of the Franciscan tempera", active in Naples between 1330 and 1345.