Augustinian friars established the early Catholic community of Macabebe on September 3, 1575, as a visita or sub-parish of the nearby Parish of San Juan Bautista Calumpit.

Two major events of the late 19th-century damaged the stone-and-brick church: the earthquakes of 1880 and the Philippine Revolution of 1898 wherein the church purportedly was set on fire by the revolutionaries under the order of General Isidoro Torres in fury of the Filipino Revolutionaries for the locals' loyalty to Spain and subsequently to the Americans.

The monotony of Neo-classical features is broken by the complex carvings on the topmost level of the three-tiered belfry attached to the right of the structure.

Also adding to the contrast are the two large wooden images and floral designs etched on the main door.

On December 12, 2009, a new, wooden altarpiece (retablo or reredos) was installed through the initiative of a Parish Construction Committee led by then-parish priest, Father Ted Valencia.