With the exception of the Rucellai Chapel, it is deconsecrated and is home to the museum dedicated to the sculptor Marino Marini.

[1] The church was built in the early Christian age, and is documented from 931; according to the historian Giovanni Villani, it was founded by Charlemagne.

Giovanni di Paolo Rucellai commissioned Leon Battista Alberti to build him a tomb in the family chapel in the church.

[2] Giorgio Vasari wrote of it in 1568:[3][note 1] For the same Rucellai family Leon Battista [Alberti] made in the same way [i.e., with architraves supported by columns] in San Pancrazio a chapel supported by large architraves placed on two columns and two pilasters, cutting through the wall of the church, which is difficult, but safe.

The exterior is decorated with marble intarsiae; inside are the tombs of Giovanni Rucellai and members of his family, and a fresco by Alesso Baldovinetti.