San Patricio is one of the 31 barrios of the municipality of Ponce, Puerto Rico.

It is one of the municipality's nine bordering barrios, along with Anón, Coto Laurel, Guaraguao, Quebrada Limón, Real, and Marueño, and the coastal barrios of Canas and Capitanejo.

Its northern edge borders the municipalities of Utuado and Jayuya.

[4] San Patricio is a rural and mountainous barrio located in the northern section of the municipality, north of downtown Ponce, at latitude 18.133586 N, and longitude -66.636444 W.[5] The toponymy, or origin of the name, is related to the Catholic Church saint San Patricio.

The community of La Gloria is located in the northern part of barrio San Patricio.