[1] Pope Paul VI visited on 16 February 1964, and Pope John Paul II visited on 31 January 1993.

San Pio X was a filming site for The Last Man on Earth (1964); it was used for the climactic scene where Dr. Morgan (Vincent Price) is cornered by human-vampire hybrids and murdered on the altar of the church.

[5][6][7] On 29 April 1969, it was made a titular church to be held by a cardinal-priest.

[8] The church is modernist in style, with a side chapel devoted to Padre Pio, with a painting of him by Ulisse Sartini.

The main altar features a bronze crucifix by Publio Morbiducci, while the pipe organ (added in 1969, and so not seen in The Last Man on Earth) was made by the Tamburini firm.