San Possidonio (Mirandolese: San Pusidònî) is a comune (municipality) in the Province of Modena in the Italian region Emilia-Romagna, located about 50 kilometres (31 mi) northwest of Bologna and about 35 kilometres (22 mi) northeast of Modena.

San Possidonio borders the following municipalities: Cavezzo, Concordia sulla Secchia, Mirandola, Novi di Modena.

San Possidonio is twinned with:

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