San Roque is a town and municipality in the Colombian department of Antioquia.

Part of the subregion of Northeastern Antioquia, it is located 1,475 m (4,839 ft) above sea level.

The municipality was founded by Francisco Martinez de Ospina on the 8 February 1880.

In 1911 the Antioquia Railway is built, traveling near the town and bringing some economy to the area.

The past history is what attracts the modern day tourists, and San Roque is often called "The Land of Cordiality" because the natives are so friendly.