San Sepolcro is a Renaissance style, Roman Catholic church and convent, located in Piacenza, Italy.
The church at the site was first built in the mid-10th century, under the patronage of a recent pilgrim to the Holy Land, but then destroyed.
During the Napoleonic period (1796), the church was deconsecrated and converted into a military hospital and stable.
The Olivetan parish priests moved to the church of the Annunziata, then San Bartolomeo.
The interior is decorated with a chiaroscuro fresco that winds like a ribbon on top of the supporting arches of the nave.