In 1550 the church was ceded to the Dominican Order which in 1587 acquired the nearby Palazzo Como to use as a convent.

From 1599 to 1620 the church underwent major reconstruction by Giovan Giacomo Di Conforto, which give the building a late-mannerist style.

Later in the 18th century, it was decorated with Baroque touches, including the staircase with finely sculpted balustrade.

The reworking of the Via Duomo shortened the nave, and deprived the church of its baroque facade and its first two chapels.

The altar is made of polychrome marble, while the transept to the right has the funereal monument of Giovanni Alfonso Bisvallo, sculpted by Girolamo D'Auria in 1617, which originally had a canvas by Luca Giordano.