San Siro is a Roman Catholic basilica located on the street of the same name, in the quartiere of the Maddalena in central Genoa, Liguria, Italy.

Legend holds that the bishop was able to banish a basilisk that dwelt in a well adjacent to the church; a plaque on a nearby house recalls the miracle.

Nearly a century later, prodded by Cardinal Vincenzo Giustiniani and the Pallavicini family, reconstruction was begun following the demands of Counter-Reformation architecture, with a main central nave.

The chapel of the Pietà was commissioned by Taddeo Carlone in 1595 (and completed by 1606 by the marble-carvers Santino Paracca, called Valsoldo, and Alessandro Ferrandino).

Other works of art include the Triumph of the Cross in the cupola by Carlone, and canvases of the Annunciation, Birth of Mary, and St Anthony by Orazio Gentileschi (the brother of Aurelio Lomi).