San Vicente Centenario (Spanish pronunciation: [sam biˈsente senteˈnaɾjo]) is a municipality in the Honduran department of Santa Bárbara.

At the time of the 2013 Honduras census, San Vicente Centenario municipality had a population of 3,601.

Of these, 70.85% were Mestizo, 26.35% White, 2.39% Black or Afro-Honduran, 0.39% Indigenous and 0.03% others.

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