Macuelizo (Spanish pronunciation: [makweˈliso]) is a municipality in the Honduran department of Santa Bárbara.

It's located a few kilometers north of the CA-4 highway, which connects San Pedro Sula to the Salvadoran border via Santa Rosa de Copán.

At the time of the 2013 Honduras census, Macuelizo municipality had a population of 34,401.

Of these, 83.03% were Mestizo, 12.36% White, 2.26% Black or Afro-Honduran, 0.86% Indigenous and 1.49% others.

This Honduras location article is a stub.