In 1604, Bernardino II di Savoy commissioned enlargement of the church.
Among the lateral altars is one dedicated to Caterina Mattei, who became a Dominican nun in this church in 1514.
On the right, an altar is dedicated to St Pope Pius V, a former Dominican, who was born in nearby Bosco Marengo.
The ceilings and cupola are decorated with quadratura frescoes (1765-1774) by Pietro Antonio Pozzo and Gallo Barelli.
In the presbytery, a painting of the Santissima Annunziata is attributed to Giovanni Battista Pozzo.