Upon her marriage, she and her husband were created Prince and Princess of Squillace, a province in the south of Italy.

Sancha's home city of Naples was no exception, and it had long been nervous about militant French interests.

It is rumored[1] that Alfonso was brutally murdered in 1500 by Cesare, due to interests with France against Naples.

Sancha, now a political embarrassment, was imprisoned in the Castel Sant'Angelo in Rome until the death of Pope Alexander in 1503.

Upon his death, she managed to regain her freedom and returned to Naples with her young nephew, Rodrigo, whom she raised as her own.