Sandra L. Thompson is an American government official who served as the director of the Federal Housing Finance Agency (FHFA) from 2022 to 2025.

[2] Following the Supreme Court's decision in Collins v. Yellen, which found that the current structure of the FHFA was unconstitutional as Congress had exceeded its authority by restricting the president's ability to dismiss the agency's head, the Biden administration announced plans to replace the current director, Mark A. Calabria, appointed under the previous president Donald Trump.

[4] On May 25, 2022, Thompson was confirmed by the Senate in a 49-46 vote, largely along party lines.

Before joining the FHFA, Thompson had served for more than 23 years in various roles at the Federal Deposit Insurance Corporation, most recently as Director of the Division of Risk Management Supervision.

Thompson is a graduate of Howard University in Washington, D.C. She has two adult sons.