She has had notable leading performances in films such as Last Night (1998), Long Life, Happiness & Prosperity (2002), Wilby Wonderful (2004), Catfight (2016), Meditation Park (2017), and Quiz Lady (2023).

She has also taken supporting roles in Bean (1997), The Princess Diaries (2001), Under the Tuscan Sun (2003), Sideways (2004), Hard Candy (2005), Rabbit Hole (2010), and Tammy (2014).

[5] In March 2019, she became the first Asian-Canadian woman to host Saturday Night Live, and was the third actress of Asian descent to do so, after Lucy Liu in 2000 and Awkwafina in 2018.

[7] Sandra Miju Oh[8] was born in Nepean, Ontario, on July 20, 1971, the daughter of middle-class South Korean immigrants Oh Young-nam, a biochemist, and Oh Jun-su (John), a businessperson.

[11] She has a brother, Ray, and a sister, Grace, and grew up in a Christian household, living on Camwood Crescent in Nepean, where she began acting and practicing ballet at age four to correct her pigeon-toed stance.

Against her parents' advice, she rejected a four-year journalism scholarship to Carleton University to study drama at the National Theatre School of Canada in Montreal, paying her own way.

[20] Oh came to prominence in her home country for her lead performance in the Canadian film Double Happiness (1994), playing Jade Li, a twenty-something Chinese-Canadian woman negotiating her wishes and those of her parents.

Oh garnered critical acclaim for her six seasons as Rita Wu, the assistant to the president of a major sports agency, on the HBO series Arliss, receiving a nomination for an NAACP Image Award for Best Supporting Actress in a Comedy Series and a Cable Ace award for Best Actress in a Comedy for her work.

In theatre, Oh has also starred in the world premieres of Jessica Hagedorn's Dogeaters at the La Jolla Playhouse and Diana Son's Stop Kiss at Joseph Papp's Public Theater in New York City.

[8] In 2005, Oh appeared in several films, including David Slade's controversial thriller Hard Candy; and the independent anthology drama 3 Needles (2005), opposite Chloë Sevigny and Olympia Dukakis, in which she plays a Catholic nun in an AIDS-stricken African village.

She co-starred in the thriller The Night Listener (2006), alongside Robin Williams and Toni Collette; in the superhero comedy Defendor (2009); Ramona and Beezus (2010); and in the critically acclaimed drama Rabbit Hole (2010), opposite Nicole Kidman and Aaron Eckhart.

In her only audiobook, she played Brigid O'Shaughnessy in a Grammy-nominated dramatization of The Maltese Falcon (2008), which also featured Michael Madsen and Edward Herrmann.

[32] In October 2014, Oh announced that she would be teaming up with Canadian director Ann Marie Fleming to collaborate on an animated feature film titled Window Horses.

[35] Beginning in April 2018, Oh began a leading role in the BBC America and BBC Three spy thriller series Killing Eve, playing British intelligence agent Eve Polastri whose quarry is psychopathic assassin Villanelle (played by Jodie Comer), with the two women developing a mutual fascination.

Oh has garnered critical acclaim for her performance on the series, with Jenna Scherer describing her in Rolling Stone as "a compulsively watchable actor – expressive and complex, blending wry wit and deep pathos.

"[38] When Vulture declared Oh the best actress currently on television, critic Matt Zoller Seitz wrote: "It's a tour de force performance, yet so self-effacing and invisible in its effects that you come away thinking that you've seen a crackling yarn with compelling characters rather than a cultural landmark.

In March 2019, she became the first Asian-Canadian woman to host Saturday Night Live, and only the third actress of Asian descent, after Lucy Liu in 2000 and Awkwafina in 2018.

[46] In 2022, Oh voiced the role of Ming Lee, the strict and overprotective mother of the main character in the Pixar animated film Turning Red.

[48] In 2023, Oh played the role of Jenny Yum, a brash, outgoing, and impulsive older sister of the main character in the 20th Century Studios comedy film Quiz Lady.

[2] Later in that year, she was one of a number of recent inductees to the Order to be included in the Canadian delegation to the state funeral of Queen Elizabeth II.

[57] On March 22, 2021, Oh gave a speech at a Stop Asian Hate rally in Pittsburgh, Pennsylvania, in response to the Atlanta spa shootings.