[1][2] She was known for playing the role of Janet Culver in the first season of the American adventure and drama television series Whirlybirds.

Spence began her screen career in 1948 with an uncredited role of a model in the film If You Knew Susie.

[4] Other films Spence appeared in included The Noose Hangs High, Woman of the North Country, Words and Music, Fighting Coast Guard, East Side, West Side, Duchess of Idaho and Annie Get Your Gun.

[6][7] In 1957, Spence joined the cast of the new syndicated adventure and drama television series Whirlybirds, in which she played the role of Janet Culver.

[3] She was replaced by actress Nancy Hale, who played the role of Helen Carter after the first season.