Her research applies statistics to microarray and genetic data; she is known as one of the founders of the open-source Bioconductor project for the development of bioinformatics software.

Her dissertation, Linkage Analysis of Complex Human Traits Using Identity by Descent Data, was supervised by Terry Speed.

Brown at Stanford University, she joined the division of biostatistics in the UC Berkeley School of Public Health as an assistant professor in 2001.

[3] Dudoit and Mark van der Laan are the authors of the book Multiple Testing Procedures with Applications to Genomics.

[5] Dudoit is the editor of the book Selected Works of Terry Speed[6] and co-editor of Bioinformatics and Computational Biology Solutions Using R and Bioconductor.