[5][6][7] Holt's acting debut, credited as Sandrine Ho, was in a 1989 episode of Friday the 13th: The Series entitled "Face of Evil".

[9] Subsequent film and television appearances include roles in Rapa-Nui, Once a Thief, Pocahontas: The Legend, The Outer Limits and Resident Evil: Apocalypse.

In 2012, she appeared in Underworld: Awakening[10] as Lida, an Antigen employee who took care of the protagonist's daughter, a prisoner named Subject Two.

In 2013 she appeared in the first season of House of Cards as Gillian Cole, the leader of a grass-roots organization called World Well that provides clean water to developing countries.

[13] In 2018, she had a recurring role on Law & Order: Special Victims Unit as Dr. Lisa Abernathy, a clinical psychologist who assesses defendants before their trials.