Kingpin prepared to settle his remaining business with his fellow mobsters by cooperating with the authorities and leaving the world of crime forever.

When Kingpin's former lieutenants in New York caught wind of his plans to sell them out in exchange for immunity, they kidnapped Vanessa, who was in town to secure the legal services of Matt Murdock and Foggy Nelson.

[6] As planned, this drove Kingpin back into the world of crime, although he found out Lynch was behind the explosion, partially due to a headache he gained, and took revenge by murdering him.

[volume & issue needed] Murdering her son had a physical toll on Vanessa, causing her to lose the will to live, which along with the injuries she sustained when she was buried alive, resulted in terminal organ failure.

When that failed, she manipulated the superhero Iron Fist into posing as Daredevil, which ultimately drove Murdock to break out of prison to find Foggy's murderer and the identity of the man impersonating him, culminating in her confronting Murdock with an offer to clear his name in exchange for him clearing Kingpin, so they would be free to try and kill each other anew.

Shortly afterwards, Vanessa died and Murdock was guilted into serving as the Kingpin's lawyer, getting the charges dropped on the grounds that the evidence was too tainted to bring him to court.

Daredevil forced the crime boss to renounce his American citizenship and leave the country forever in exchange for his legal services, stating that any attempt to continue their vendetta would be an insult to the memory of Vanessa.

[volume & issue needed] The Arbiters bring Vanessa back as a revenant as a part of a test intended to gauge the Kingpin's worth as the head of the Hand.

[10] Reluctant to combat her, Fisk tries to appeal to whatever humanity that she may still have left in her, and kills her when she still flings her weapons at him, unaware that she was aiming at the assassin approaching him from behind.

[12] After Mayor Fisk starts planning to have Peter Parker killed, as he is the roommate of Fred Myers who is blackmailing him, the mysterious undead entity Kindred appears in his cabinet.

He kills Fisk's associates using supernatural abilities and forces him to back off Parker after revealing he is in possession of Vanessa's soul.

[15] In the Marvel/DC crossover book Batman & Spider-Man: New Age Dawning #1, Vanessa is infected with terminal cancer by Ra's al Ghul, who offers the Kingpin the cure for it in exchange for his help in a plot that will destroy New York.

She appears ready to take charge of her husband's former empire, as her chauffeur calls her "Madam Kingpin", but in issue #22, she is ambushed and killed by Nick Fury.

After fleeing in horror and being killed in a car accident, Wilson spearheaded the creation of the "Super-Collider" to find alternate variants of his family in the multiverse.