They rose to fame in the early 1990s as child stars and reached the height of their success during teenage, as albums Era Uma Vez... Ao Vivo (1998), As Quatro Estações (1999), Quatro Estações: O Show (2000) and Sandy & Junior (2001) sold more than a million units, with the second and third being among the best-selling albums of all time in Brazil.

In addition to their success in the music industry, the sibling's name became a strong brand, with more than 300 licensed products which made R$300 million a year.

After the duo's disbandment in December 2007, Sandy spent the next two years concentrating efforts on producing her debut solo album.

In 2008, Sandy married musician Lucas Lima and graduated from Pontifical Catholic University of Campinas with a degree in languages and literature.

In 2010, she released her debut solo album, Manuscrito, which was preceded by lead single "Pés Cansados" and certified platinum by Pro-Música Brasil (PMB).

Her first concert tour as a solo artist was recorded in August 2011 and gave rise to her first video/live album, Manuscrito Ao Vivo, released in November that year.

In 2016, she released her second live album, Meu Canto, which was preceded by lead single "Me Espera" and reached the top of PMB's DVD chart.

As an actress, she had leading roles in the television series Sandy & Junior (1999–2002) and As Brasileiras (2012), telenovela Estrela-Guia (2001), and films Acquária (2003) and Quando Eu Era Vivo (2014).

"[10] The album sold 1.2 million copies worldwide and was preceded by its lead single "Love Never Fails" (also recorded in Portuguese, Spanish and French language.

On April 17, 2007, Sandy & Junior announced that an MTV Unplugged album to be recorded in May 2007 would be their final work together, through a video posted on their website addressed to their fans and in a press conference, stating also that their career as a duo would be over at the end of 2007.

[12] Of the important moments in their career, several stand out: a show in João Pessoa (2001) to over 1.2 million people, Rock in Rio III, and a concert in Maracanã Stadium (which gave rise to a CD and DVD).

Sandy's first solo recording was a feature on Andrea Bocelli's "Vivo Por Ella" that was released in 1997, peaking at number one on the Brazilian Hot 100 chart.

After this presentation, Sandy partnered with Gilberto Gil, Milton Nascimento, Caetano Veloso, among other renowned singers and musicians of Brazilian popular music.

[14] In November 2008, Sandy, alongside Paula Toller opened the 9th Annual Latin Grammy Awards, paying tribute to Carmen Miranda.

[15] In May 2009, Sandy, alongside electronic duo Crossover, peaked at number 13 in the Canada's dance chart with the single "Scandal".

The tour was part of the Banco do Brasil's sponsored project Circuito Cultural; It had 10 sold-out concerts and received positive reviews from music critics.

In January 2014, Sandy starred alongside Antônio Fagundes and Marat Descartes in the film Quando Eu Era Vivo.

[28] In April 2015, Sandy was hired to replace Ivete Sangalo as a judge for the second season of the Brazilian version (Superstar) of reality television singing competition Rising Star, joining Thiaguinho and Paulo Ricardo.

[37] In 2017, Sandy featured in Luan Santana song "Mesmo Sem Estar", which peaked at number 4 on the Billboard Brazil Hot 100 Airplay.

In March 2019, Sandy and her brother Junior Lima announced the Nossa História tour in celebration of the 30th anniversary of the duo's first televised performance, which took place in 1989.

[49] Her other musical influences include John Mayer, Coldplay, Norah Jones, Damien Rice, Sarah McLachlan and jazz singer Ella Fitzgerald.

[49] Her early influences includes Mariah Carey, Céline Dion, Whitney Houston and also her father, sertanejo singer Xororó.

[58] Sandy had previously dated musician Lucas Scholles Lima for five months in 1999; they resumed their relationship in 2004, announced their engagement in 2007, and were married on September 12, 2008.