It is famous for its remoteness and for its rich array of wildlife, including Asian elephants, gaurs, sambar deers, barking deers, serows, Asian black bears, sun bears, leopards, clouded leopards, Asian golden cats, marbled cats, leopard cats, binturongs, western hoolock gibbons, slow lorises, crab-eating macaques, capped langurs, reticulated pythons, Arakan forest turtles, Asian giant tortoises, great hornbills and spotted owlets.

There have also been uncertain reports of vagrant tigers in the forest reserve by local indigenous people.

Its physiography is categorized as Northern and Eastern Hills; its beat information is 285 Sangu Mouza.

Visitors enter this wildlife sanctuary mostly for nature trails, picnic sites, etc.

1200–1300 people depend on the wildlife sanctuary for resources like fuel wood, sun grass, bamboo, medicinal plant and others.

Severe encroachment leading to expansion of settlements and agriculture, tree poaching, hunting, shooting, collection of fuel wood, bamboo and cane and other forest products are the major causes for the exploitation of resources of the national park.

On the other hand, functioning sawmills in the vicinity and unemployment are the major underlying factors for the marked dependency of the local communities upon the park.

Less stringent monitoring and a negative influence of some locally powerful individuals have further exacerbated the sustainable maintenance of the sanctuary.

The Chittagong Hill Tracts have been broadly classified as the tropical evergreen or semi-evergreen types, which, according to a source, supply around 40% of the commercial timber.

Sangu River originates in the Arakan Hills of Myanmar and enters Bangladesh near Remarki (Thanchi upazila of Bandarban district).

The most important commercial timber species of the Sangu Matamuhari is Jarul, Gamar, Garjan, Chapalish, Toon, Koroi, Civit, Champa, Simul, Chandul, etc.

Also there was a picture of a leopard, taken by a camera trap, close to Sangu Wildlife Sanctuary in 2015.

However, due to settlement of refuge, the vegetation of these areas diminished and became uninhabitable for elephants, which now can be seen in Sangu Mouza only.

[11] There are reports of tigers in the mixed evergreen hill tract valleys of Sangu-Matamuhuri, which are contiguous with forests in India and Myanmar respectively.