Part of it was located on the territory of the Lordship of Prilep, a realm in Macedonia ruled by the Ottoman vassal Prince Marko until his death in the Battle of Rovine.

[5] In 1464 and 1465, the sanjakbey of the Sanjak of Ohrid was Ballaban Badera, famous for his battles against Skanderbeg,[6][7] replacing Şeremet bey on this position.

[14] In the autumn of 1794, Kara Mahmud Bushati, who was the pasha of the Pashalik of Scutari, gained control over the Sanjak of Ohrid.

[23] In 1467 many Christians from Skopje, Ohrid, Serres and Kastoria were forcibly deported to Elbasan, a new Ottoman fortress in Albania.

[26] In 1613 Ottoman authorities ordered the destruction of all newly built Christian churches in the villages of the Sanjak of Ohrid.