He made his Premier League debut in 2013 for Rajasthan Royals and won the Emerging Player of the Year[broken anchor].

[2][3] Samson was born on 11 November, 1994[4] into a Malayali Christian family[5] in Pulluvila, a coastal village near Vizhinjam, in the Thiruvananthapuram district of Kerala, India.

[8] His elder brother Saly Samson has represented Kerala in junior cricket[9][10] and currently works in the AG's office.

[25] His performance in the 2010-11 Cooch Behar Trophy[26] earned him a spot in the India U-19 team that played the 2012 ACC Under-19 Asia Cup held in Malaysia in June 2012.

[6][27] His dismal show in the tournament meant that he failed to get selected to India's squad for the 2012 Under-19 Cricket World Cup that followed.

[29] He scored two half-centuries in India U-19's Youth Test series against Sri Lanka held from July to August 2013.

[41] He was named in the Kerala squad for playing the 2011-12 Vijay Hazare Trophy[42] and made his List-A debut on 23 February 2012 against Andhra Pradesh in the season.

[52] On the Australia A Team Quadrangular Series in 2014, he finished as India A's highest run-scorer with 244 runs from seven innings, with an average of 81.33.

[64][65] He was issued a show-cause notice by Kerala Cricket Association for alleged acts of indiscipline during a match in the tournament.

[70][71] In November 2017, he was appointed as the captain of the Board President's XI, replacing an injured Naman Ojha for a two-day tour match against Sri Lanka.

[75][76] In October 2019, during the 2019–20 Vijay Hazare Trophy match between Kerala and Goa, Sanju doubled his maiden List-A century.

[82] The impact made from this innings went on to earn him a national call-up after four years, as he was selected to play the Bangladesh series that followed.

[93] In December 2014, he was named in India's 30-member probables list for the 2015 Cricket World Cup but did not make to the final squad.

[94] In July 2015, he was drafted into the Indian squad against Zimbabwe for an ODI and two T20I matches as an injury replacement for Ambati Rayudu.

[96] After a top-order collapse, Samson added 36 runs in the sixth wicket, along with Stuart Binny in a low-score chase.

[102] He was selected for the T20I series of the India tour of New Zealand replacing an injured Shikhar Dhawan[103] but failed to create an impact with the bat with a string of low scores.

[113] He disappointed with the bat in the T20 series in which a depleted Team India lost to Sri Lanka 2–1 with Samson scoring only 34 runs.

[114][115] He missed out from the Indian squad for the 2021 ICC Men's T20 World Cup, held in October 2021, because of his poor form in T20s.

[125] On 29 July 2022, he was added to India's Twenty 20 International (T20I) squad, also for their series against West Indies, after KL Rahul tested positive for COVID-19 and scored 30* and 15 in the last two matches respectively.

[137] On 30 April 2024, he was selected in India's 15 member Squad for the 2024 ICC Men's T20 World Cup to be held in USA and West Indies which they won.

In the third match of the series, he scored his maiden T20I century, registering 111 runs off 47 balls and contributing to India's victory.

[140] Along with Tilak Varma who scored another century he put up a record unbeaten 210 run 2nd wicket partnership to guide India to mammoth total of 283 in the 4th T20.

Samson was named by Kolkata Knight Riders in its player pool ahead of 2009 Indian Premier League.

[145] He made his IPL debut for Rajasthan against Kings XI Punjab on 14 April 2013 after the regular wicket-keeper Dishant Yagnik failed to recover from an injury.

[152] In 2016, Delhi Capitals signed Samson[153] after Rajasthan was banned from the competition for two years after being found guilty in illegal betting and match-fixing probe.

[167] In 2023, he played as a captain of Rajasthan Royals and scored 362 runs with 3 half centuries in season and finished 5th on points table.

In this season, Rajasthan Royals ended up the league stage at 3rd on points table, and went on to Qualifier 2 but defeated by Sunrisers Hyderabad by 36 runs.

[177][178] He holds the bat high on the handle and keeps a loose shoulder,[179] and is equipped with fast hands, powerful forearms and excellent hand-eye coordination.

[198] Sanju married his long-time girlfriend Charulatha Remesh, a native of Thiruvananthapuram, on 8 September 2018 through his social media platforms.

[201] The wedding reception took place in Nalanchira on the same day with the only notable cricketer to attend being Samson's former coach and mentor, Rahul Dravid.