Sannazzaro de' Burgondi is a comune (municipality) in the Province of Pavia in the Italian region Lombardy, located about 45 km southwest of Milan and about 20 km southwest of Pavia, in Lomellina, on the Agogna River.

Sannazzaro de' Burgondi borders the following municipalities: Corana, Cornale e Bastida, Dorno, Ferrera Erbognone, Mezzana Bigli, Pieve Albignola, Scaldasole, Silvano Pietra.

It is the ancestral home of the Sannazzaro family, who later extended their rule to the Oltrepò Pavese and Montferrat.

Sannazzaro was part of Savoy from 1713, and, after its annexation to the unified Italy in 1859, received its current name in 1863.

Sannazzaro, whose economy was once based on the production of tools (wooden and metal screws), is home to one of the largest refineries in Italy, owned by ENI.