It contains a number of prominent artworks, including paintings by Sante Cattaneo, Paolo Veronese, and Enea Salmeggia.

In 1479, the church was finished and the relics of the ancient bishop of Brescia, San Paterio were interred in the crypt under the presbytery.

The second and third chapels have altarpieces by Sante Cattaneo depicting respectively Jesus distributes Eucharist and Saints Benedict of Nursia and Scholastica.

The ceiling decoration dates to 1776, by Pietro Melchiorre Ferrari and Antonio Grassi, and encircles three large ovals by Cattaneo depicting San Paterio offers his writings to St John Baptist, Coronation of the Virgin and the Saints Benedict of Nursia and Scholastica.

The dome was decorated (now damaged) by Antonio Mazza (quadratura) and Carlo Innocenzo Carloni (figures) with the Descent of Holy Spirit to Mary and Apostles, and the Four Evangelists.

These two artists also decorated the choir ceiling with the Glory (Exaltation) of St Euphemia and figures of faith and charity.