Sant'Agnello Maggiore, also called Sant'Aniello a Caponapoli or Santa Maria Intercede, is a church in the historical center of Naples, Italy.

In the 9th century, Bishop Athanasius of Naples built a new religious building and dedicated to the abbot Saint Agnello and placed his relics in the church.

During the Middle Ages, the cult of Sant'Agnello became increasingly important and the end of the 13th century till 1517, the church was under the direction of a rector, which from there on was a priest of the order of Canons Regular of the Lateran Congregation of the Most Holy Savior .

On August 7, 1809, the monastic order in charge of the church was suppressed, and on January 12, 1809, the monastery was sold by the Minister of Finance to a private citizen Cosimo d'Orazio.

By 1913, the parish was transferred to the nearby church of Santa Maria di Costantinopoli due to the precarious state of the structure.