The Chapel of St Anne (Maltese: Il-Kappella ta' Sant'Anna) is a small Roman Catholic church located in the village of Qrendi, Malta.

This chapel owns it origins to Giovanni Schembri who built it as a fulfillment to a vow he made during the Great Siege of Malta of 1565.

Schembri vowed to build a chapel dedicated to the Virgin Mary should he and his family escape the perils of the Great Siege.

That same year the chapel was restored by the initiative of the parish priest Reverend Anton Mizzi.

The titular painting, from an unknown artist, depicts the Virgin Mary with baby Jesus, St. Anne, St. John the Baptist, and St. Venera.