It was restored and rebuilt several times, finally in the 18th century, when the façade was altered, stucco applied to the central nave and the ceiling vaults of the interior and three altarpieces added - 'Jesus among the Doctors' in the Chapel of St Francis, a 1771 'Visitation of the Virgin' by Giambattista Canal and 'The Adoration of the Magi' by Jacopo Marieschi (the third of these has now been moved elsewhere).

Its right side overlooks the Giudecca canal and has a portico with Doric style columns, taken from the nearby church and monastery of Santi Biagio e Cataldo during the latter's 1593 restoration.

In a niche inside the porch is a Gothic-style image of the 'Holy Bishop' below a 14th-century crucifixion with donors in the Byzantine style, set in a three-faceted bezel.

A chapel now houses the remains of Blessed Giuliana of Collalto, translated there in 1822, again from santi Biagio e Cataldo.

The left aisle also houses an 18th-century marble sculpture of the Virgin Mary and Christ by Gianmaria Morlaiter in the left, whilst the firsts altarpiece in the right aisle houses the central part of a triptych of saint Roch and the angel under a lunette of the Virgin and Child, both by Bartolomeo Vivarini and dating to 1480.